Crystal nucleation for a model of globular proteins
نویسندگان
چکیده
منابع مشابه
Crystal nucleation for a model of globular proteins.
A continuum model of globular proteins proposed by Talanquer and Oxtoby [J. Chem. Phys. 109, 223 (1998)] is investigated numerically, with particular emphasis on the region near the metastable fluid-fluid coexistence curve. Classical nucleation theory is shown to be invalid not only in the vicinity of the metastable critical point but also close to the liquidus line. An approximate analytic sol...
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Metastability and nucleation in the dilute fluid phase of a simple model of globular proteins
The dilute fluid phase of model globular proteins is studied. The model possesses a fluid-fluid transition buried within the fluid-crystal coexistence region, as do some globular proteins. If this fluid-fluid transition is not buried deep inside the fluid-crystal coexistence region the crystalline phase does not nucleate within the dilute fluid. We link this lack of nucleation of the crystal to...
متن کاملEstimations of the size of nucleation regions in globular proteins.
Folding of many single-domain proteins has been described using the nucleation-collapse (NC) mechanism. According to NC, folding (formation of secondary structures and tertiary interactions) and chain collapse occur synchronously upon formation of native-like structures involving a critical number of residues. Using simple nucleation theory together with structure-based thermodynamic data, the ...
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Distinct structural regions have been found in several globular proteins composed of single polypeptide chains. The existence of such regions and the continuity of peptide chain within them, coupled with kinetic arguments, suggests that the early stages of three-dimensional structure formation (nucleation) occur independently in separate parts of these molecules. A nucleus can grow rapidly by a...
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ژورنال
عنوان ژورنال: The Journal of Chemical Physics
سال: 2004
ISSN: 0021-9606,1089-7690
DOI: 10.1063/1.1695321